Targeting the DNA Damage Response for Anti-Cancer Therapy By John Pollard
English | PDF,EPUB | 2018 | 402 Pages | ISBN : 3319758349 | 29.64 MB
Over the past decade a complex role for DNA damage response (DDR) in tumorigenesis has emerged. A proficient DDR has been shown to be a primary cause for cellular resistance to the very many DNA damaging drugs, and IR, that are widely used as standard-of-care across multiple cancer types. It has also been shown that defects in this network, predominantly within the ATM mediated signaling pathway, are commonly observed in cancers and may be a primary event during tumorigenesis.