The Structural Basis of Arrestin Functions By Vsevolod V. Gurevich
English | PDF | 2017 | 302 Pages | ISBN : 331957552X | 6.95 MB
This volume summarizes our current understanding of the structural basis of the functions of arrestin family of proteins. Arrestins were first discovered as key players in the desensitization of G protein-coupled receptors (GPCRs). Recent studies showed that arrestins are important signal transducers in their own right, organizing multi-protein complexes and scaffolding numerous signaling cascades that regulate cell proliferation, differentiation, and apoptotic death.