Genetic Engineering of Viruses and Viral Vectors by National Academy of Sciences
English | 1 Jan. 1996 | ISBN: 0309058368 | 144 Pages | PDF | 4 MB
Nearly two centuries ago, Jenner used a live virus of another species to combat smallpox—one of the most lethal human pathogens known. In the intervening years, science has provided the tools to produce by design in the laboratory other live viruses capable of protecting against their more lethal siblings. We have learned to attenuate human pathogenic viruses by passage in nonhuman hosts, by cultivation at lower temperature, and by the genetic engineering of mutations in viral genomes.