Diverse Effects of Hypoxia on Tumor Progression By M. Celeste Simon
English | PDF | 2010 | 151 Pages | ISBN : 3642133282 | 3.15 MB
Solid tumors frequently contain areas of oxygen deprivation (hypoxia) due to rapid cell proliferation and/or vascular insufficiency. The presence of hypoxic domains typically correlates with poor patient prognosis, due to the relative resistance of hypoxic cells to conventional cancer therapies and effects of O2 availability on disease progression. The response of malignant cells to hypoxia has been the focus of intense research over the last decade.