Drug Delivery to the Brain: Physiological Concepts, Methodologies and Approaches By Margareta Hammarlund-Udenaes, Elizabeth C.M. de Lange, Robert G. Thorne
English | EPUB | 2014 | 731 Pages | ISBN : 1461491045 | 9.32 MB
The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood –brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few.